abstract：:To assess the rapidly changing psychological status of nurses during the acute phase of the 2003 SARS outbreak, we conducted a prospective and periodic evaluation of psychiatric morbidity and psychological adaptation among nurses in SARS units and non-SARS units. Nurse participants were from two SARS units (regular SA...

journal_title：Journal of psychiatric research

authors： Su TP,Lien TC,Yang CY,Su YL,Wang JH,Tsai SL,Yin JC

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells. METHOD:Fifty-seven Chinese psychiatric inpatients who met DSM-IV diagnosis of...

journal_title：Journal of psychiatric research

authors： Ling SH,Tang YL,Jiang F,Wiste A,Guo SS,Weng YZ,Yang TS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Gray matter reduction and ventricular enlargement belong to the best replicated findings in schizophrenia. Brain morphologic changes were also found in non-schizophrenic family members (FM). The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic cha...

journal_title：Journal of psychiatric research

authors： Schneider-Axmann T,Kamer T,Moroni M,Maric N,Tepest R,Dani I,Honer WG,Scherk H,Rietschel M,Schulze TG,Müller DJ,Cordes J,Schönell H,Steinmetz H,Gaebel W,Vogeley K,Kühn KU,Wagner M,Maier W,Träber F,Block W,Schild

更新日期：2006-10-01 00:00:00

abstract：:The deficits of attention contribute significantly to the clinical picture of functional disability seen in schizophrenia, but there is no consensus as to whether this cognitive function can be fractionated to allow further characterisation of the impairment. We examined fifteen patients with chronic schizophrenia and...

journal_title：Journal of psychiatric research

authors： Birkett P,Brindley A,Norman P,Harrison G,Baddeley A

更新日期：2006-10-01 00:00:00

abstract：:The implicit and explicit memory in patients with obsessive-compulsive disorder (OCD) was investigated using the event-related potential (ERP). For the assessment of implicit memory, a lexical decision task was administered. Among a total of 320 words and 140 non-words, 200 words were repeated, while the remaining 120...

journal_title：Journal of psychiatric research

authors： Kim MS,Kim YY,Kim EN,Lee KJ,Ha TH,Kwon JS

更新日期：2006-09-01 00:00:00

abstract：UNLABELLED:This prospective study aimed to assess symptomatic evolution of patients diagnosed with Upper Airway Resistance Syndrome (UARS) four and half years after the initial UARS diagnosis. For this purpose, 138 UARS patients were contacted by mail between 43 and 69 months after the initial evaluation; 105 responded...

journal_title：Journal of psychiatric research

authors： Guilleminault C,Kirisoglu C,Poyares D,Palombini L,Leger D,Farid-Moayer M,Ohayon MM

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:A vast amount of studies demonstrates the presence of psychomotor slowing in schizophrenia. The objective of the present study was to investigate whether this overall psychomotor slowing can be divided into distinct processes that differentially affect cognitive functioning in schizophrenia. METHODS:The pen...

journal_title：Journal of psychiatric research

authors： Morrens M,Hulstijn W,Van Hecke J,Peuskens J,Sabbe BG

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:(a) To investigate the correlation between clinical symptoms and neurological soft signs in patients suffering from their first episode of schizophrenia and (b) to examine the relationship between soft signs and the reactivity of first episode treatment. METHODS:The trial included 92 male patients undergoing...

journal_title：Journal of psychiatric research

authors： Prikryl R,Ceskova E,Kasparek T,Kucerova H

更新日期：2006-03-01 00:00:00

abstract：:The antisaccade task is well suited to study the interplay between environmental stimuli and action goals in controlling behavior. It requires subjects to look to the mirror position of visual stimuli. Schizophrenia patients usually show enhanced rates of erroneous saccades toward the stimulus. The present study was d...

journal_title：Journal of psychiatric research

authors： Reuter B,Herzog E,Kathmann N

更新日期：2006-03-01 00:00:00

abstract：:Antipsychotic drugs, potent dopamine receptor antagonists, are commonly used in the treatment of psychotic and affective illness. The discovery of antagonistic interactions between A2A adenosine receptors (ARs) and D2 dopamine receptors (DRs) in the central nervous system suggests that the adenosine system may be invo...

journal_title：Journal of psychiatric research

authors： Martini C,Tuscano D,Trincavelli ML,Cerrai E,Bianchi M,Ciapparelli A,Alessio L,Novelli L,Catena M,Lucacchini A,Cassano GB,Dell'Osso L

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess whether individual or clusters of psychiatric symptoms can differentiate patients with psychotic major depression (PMD) from those with nonpsychotic depression (NPMD). METHOD:Data were pooled from two studies investigating patients with moderate depression. A total of 129 ...

journal_title：Journal of psychiatric research

authors： Keller J,Gomez RG,Kenna HA,Poesner J,DeBattista C,Flores B,Schatzberg AF

更新日期：2006-02-01 00:00:00

abstract：:The objective was to explore psychiatric disorders as potential predictors of sleep duration. A cross-sectional survey study with a probability sample of residents of a northern German area was carried out. There were 4075 study participants, aged 18--64 years, with a participation rate of 70.2%. Face-to-face in-home ...

journal_title：Journal of psychiatric research

authors： John U,Meyer C,Rumpf HJ,Hapke U

更新日期：2005-11-01 00:00:00

abstract：:Schizophrenic patients are known to experience difficulties in emotional information processing, yet knowledge of their physiological responsivity to emotional stimuli is limited. The purpose of this study was to investigate the physiological reactions of schizophrenic patients to emotional stimuli. We presented pictu...

journal_title：Journal of psychiatric research

authors： Hempel RJ,Tulen JH,van Beveren NJ,van Steenis HG,Mulder PG,Hengeveld MW

更新日期：2005-09-01 00:00:00

abstract：:Although schizophrenia and obsessive-compulsive disorder (OCD) are distinct diagnostic entities, there are substantial areas of overlap between the two disorders in clinical characteristics, affected brain areas and pharmacotherapy. Though OCD patients apparently do not have increased risk for developing schizophrenia...

journal_title：Journal of psychiatric research

authors： Poyurovsky M,Koran LM

更新日期：2005-07-01 00:00:00

abstract：:Maternal exposure to viral infection has been associated with an increased risk of schizophrenia in the offspring, and it has been suggested that the maternal immune response may interfere with normal fetal brain development. Although studies in rodents have shown that perinatal viral infections can lead to neuropatho...

journal_title：Journal of psychiatric research

authors： Zuckerman L,Weiner I

更新日期：2005-05-01 00:00:00

abstract：:Most of the available evidence on neuropsychological functioning in anxiety disorders is based on clinical samples, investigating persons affected by obsessive-compulsive disorder. Knowledge is sparse regarding cognitive functions in other types of anxiety disorders. The aim of this study was to examine whether person...

journal_title：Journal of psychiatric research

authors： Airaksinen E,Larsson M,Forsell Y

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:It has been proposed that the often found hyperintensities on MRI representing vascular changes might be correlated with a worse outcome of cognitive malfunction in depression. The purpose of this study was to evaluate neuropsychological status in the acute depressed state and following remission and to in...

journal_title：Journal of psychiatric research

authors： Neu P,Bajbouj M,Schilling A,Godemann F,Berman RM,Schlattmann P

更新日期：2005-03-01 00:00:00

abstract：:One of the most characteristic alterations in depression is a disturbed regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in...

journal_title：Journal of psychiatric research

authors： Ising M,Lauer CJ,Holsboer F,Modell S

更新日期：2005-01-01 00:00:00

abstract：:The DEX/CRH test is now a well established method to test the hypothalamic-pituitary-adrenal (HPA) axis for depressed patients in an inpatient setting. The aim of this study was to evaluate this test in an outpatient population suffering from major depression compared to a healthy control group. The main result is a s...

journal_title：Journal of psychiatric research

authors： Gervasoni N,Bertschy G,Osiek C,Perret G,Denis R,Golaz J,Rossier MF,Bondolfi G,Aubry JM

更新日期：2004-11-01 00:00:00

abstract：:In previous work we demonstrated an early, robust and sustained effect for sertraline vs placebo on irritability and anger in subjects with PTSD. In this report, we explore the same dataset to assess whether a clinician might usefully predict ultimate response to sertraline, on the basis of its effect upon anger after...

journal_title：Journal of psychiatric research

authors： Davidson J,Landerman LR,Clary CM

更新日期：2004-09-01 00:00:00

abstract：:Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a pat...

journal_title：Journal of psychiatric research

authors： Zimmermann U,Spring K,Wittchen HU,Himmerich H,Landgraf R,Uhr M,Holsboer F

更新日期：2004-07-01 00:00:00

abstract：:An increased incidence of schizophrenia has been associated with several perinatal insults, most notably maternal infection during pregnancy and perinatal hypoxia. This study used a rat model to directly test if maternal exposure to bacterial endotoxin (lipopolysaccharide, LPS) during pregnancy alters behaviors releva...

journal_title：Journal of psychiatric research

authors： Fortier ME,Joober R,Luheshi GN,Boksa P

更新日期：2004-05-01 00:00:00

abstract：:Many studies have demonstrated that venlafaxine is an efficacious and safe treatment for major depressive disorder (MDD). This double-blind, placebo-controlled study was performed to evaluate the efficacy of venlafaxine extended-release (XR) (75-225 mg/day) in the prevention of relapse of depression. Patients with MDD...

journal_title：Journal of psychiatric research

authors： Simon JS,Aguiar LM,Kunz NR,Lei D

更新日期：2004-05-01 00:00:00

abstract：:There is growing evidence for a relationship between the duration of untreated psychosis (DUP) and the prognosis in schizophrenia. The objective of this study is to evaluate whether DUP and premorbid level of social functioning are related to treatment response in acute treatment of first-episode schizophrenia. Sevent...

journal_title：Journal of psychiatric research

authors： Uçok A,Polat A,Genç A,Cakir S,Turan N

更新日期：2004-03-01 00:00:00

abstract：:For over a century, clinicians have struggled with how to conceptualize the primary psychoses, which include psychotic mood disorders and schizophrenia. Indeed, the nature of the relationship between mood disorders and schizophrenia is an area of ongoing controversy. Psychotic bipolar disorders have characteristics su...

journal_title：Journal of psychiatric research

authors： Ketter TA,Wang PW,Becker OV,Nowakowska C,Yang Ys

更新日期：2004-01-01 00:00:00

abstract：:Alterations in the density and size of pyramidal neurons in the prefrontal cortex have been described in schizophrenia and mood disorder. However, the changes are generally modest and have not always been replicated. We investigated the possibility that specific pyramidal neuron sub-populations, defined by their immun...

journal_title：Journal of psychiatric research

authors： Law AJ,Harrison PJ

更新日期：2003-11-01 00:00:00

abstract：:Genetic factors contribute to the risk of psychopathology in many psychiatric conditions, but the specific genes are yet to be identified. Neurotransmitter alterations are implicated in the etiology of psychopathology based, in part, on studies of neurotransmitter receptors and their biosynthetic or degradative enzyme...

journal_title：Journal of psychiatric research

authors： Arango V,Huang YY,Underwood MD,Mann JJ

更新日期：2003-09-01 00:00:00

abstract：:Because repetitive transcranial magnetic stimulation (rTMS) is capable of inducing lasting alterations of cortical excitability, it represents a promising therapeutic tool in several neuropsychiatric disorders. However, rTMS, especially when applied chronically, may cause harmful effects in the stimulated tissue. To s...

journal_title：Journal of psychiatric research

authors： Liebetanz D,Fauser S,Michaelis T,Czéh B,Watanabe T,Paulus W,Frahm J,Fuchs E

更新日期：2003-07-01 00:00:00

abstract：:Body weight gain frequently occurs during drug treatment of psychiatric disorders and is often accompanied by increased appetite or food craving. While occurrence and time course of this side effect are difficult to predict, it ultimately results in obesity and the morbidity associated therewith in a substantial part ...

journal_title：Journal of psychiatric research

authors： Zimmermann U,Kraus T,Himmerich H,Schuld A,Pollmächer T

更新日期：2003-05-01 00:00:00

abstract：:Previously it was shown that hyperleptinemia ensues from the therapeutically induced weight gain in patients with anorexia nervosa (AN). However, not all studies have been able to confirm this finding. To further investigate leptin secretion during weight gain in AN and potential functional implications serum leptin l...

journal_title：Journal of psychiatric research

authors： Holtkamp K,Hebebrand J,Mika C,Grzella I,Heer M,Heussen N,Herpertz-Dahlmann B

更新日期：2003-03-01 00:00:00

abstract：:It has been shown that antidepressants increase the expression of CREB (cAMP-response-element-binding-protein) and BDNF (brain derived neurotrophic factor) in vivo. Apparently inconsistent to these survival-promoting properties for many years antidepressants are known to induce apoptosis in various cell types in vitro...

journal_title：Journal of psychiatric research

authors： Koch JM,Kell S,Aldenhoff JB

更新日期：2003-01-01 00:00:00

abstract：:In order to investigate the functional basis of the frequently described deficits of schizophrenia patients in Trail Making Test B (TMT-B) performance, the performance process was analyzed based on the interaction of eye and hand movements. In a longitudinal design, 23 acute schizophrenia patients, 17 acute depressive...

journal_title：Journal of psychiatric research

authors： Wölwer W,Gaebel W

更新日期：2002-11-01 00:00:00

abstract：:Few studies have assessed the familiality of clinical characteristics in schizophrenia. Therefore, we set out to investigate the familiality of the following characteristics; age of onset, course of disorder, employment status at onset, impairment during disorder, marital status at onset, mode of onset and premorbid f...

journal_title：Journal of psychiatric research

authors： Wickham H,Walsh C,Asherson P,Gill M,Owen MJ,McGuffin P,Murray R,Sham P

更新日期：2002-09-01 00:00:00

abstract：:This study investigated the changes of the neuropsychological functions over a 4-month period of treatment in patients with obsessive-compulsive disorder (OCD). Thirty-nine OCD patients and 31 healthy controls were evaluated with neuropsychological and clinical tests. The same tests were readministered 4-months after ...

journal_title：Journal of psychiatric research

authors： Kim MS,Park SJ,Shin MS,Kwon JS

更新日期：2002-07-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been found to ameliorate symptoms in major depression. However, its mechanism of action has to be further elucidated and the relationship between responses to rTMS and other antidepressant interventions except electroconvulsive therapy has not been investigated t...

journal_title：Journal of psychiatric research

authors： Padberg F,Schüle C,Zwanzger P,Baghai T,Ella R,Mikhaiel P,Hampel H,Möller HJ,Rupprecht R

更新日期：2002-05-01 00:00:00

abstract：:The current investigation examines perceived family relationships prior to the onset of psychopathology in a sample at high-risk for schizophrenia. Previous research suggests that environmental factors, such as family relationships, may contribute to later schizophrenia in high-risk individuals. This investigation ext...

journal_title：Journal of psychiatric research

authors： Schiffman J,LaBrie J,Carter J,Cannon T,Schulsinger F,Parnas J,Mednick S

更新日期：2002-01-01 00:00:00

abstract：:In this cross-sectional study we explored in 101 depressive in-patients (DSM III-R) the association between level of trait anxiety and variables that have been investigated previously to discern primary and secondary depression, respectively. Besides, we explored the influence of trait anxiety level on difference in t...

journal_title：Journal of psychiatric research

authors： Bruijn JA,Moleman P,van den Broek WW,Mulder PG

更新日期：2001-11-01 00:00:00

abstract：:Experimental evidences suggest that Panic Disorder (PD) is characterized by abnormalities in respiratory and vestibular functions. We studied balance system function in patients with PD and its relationships with CO(2) reactivity and clinical characteristics. Nineteen patients with PD with/without agoraphobia underwen...

journal_title：Journal of psychiatric research

authors： Perna G,Dario A,Caldirola D,Stefania B,Cesarani A,Bellodi L

更新日期：2001-09-01 00:00:00

abstract：:Williams syndrome (WMS) is a rare genetic disorder characterized by relative preservations of language ability and facial processing despite deficits in overall intelligence, problem solving, and visuospatial processing. Subjects with WMS also display hypersocial behavior and excessive linguistic affect during convers...

journal_title：Journal of psychiatric research

authors： Schmitt JE,Eliez S,Warsofsky IS,Bellugi U,Reiss AL

更新日期：2001-07-01 00:00:00

abstract：:A variety of test procedures are used in preclinical research on behavioral pharmacology and to dissociate behavioral differences or pharmacologically induced behavioral alterations several independent tests are usually performed. In the present study we introduce a modified hole board procedure for mice which allows ...

journal_title：Journal of psychiatric research

authors： Ohl F,Sillaber I,Binder E,Keck ME,Holsboer F

更新日期：2001-05-01 00:00:00